However aqueous solutions of propylene glycol greater than 22% by weight, if heated sufficiently, will produce flammable vapors. Propylene glycol alginate is fully biodegradable and the products of degradation are more toxic than the product itself. Msds propylene glycol antifreeze and engine coolant. Under ordinary conditions, mild steel is a satisfactory material of construction. Propylene oxide is the principal product of the reaction of propylene glycol over a.
Reverse osmosis antiscalant synthetic polyelectrolyte. It is labeled an organic compound in chemistry due to its carbon attributes. Propylene glycol, food and flavor ingredient, fema no 2940. Drug products containing certain active ingredients offered over the counter otc for certain uses. Pg uspep is tested for compliance with the current united states pharmacopeia usp. Exposures to propylene glycol having no adverse effects on the mother should have no effect on the fetus. Propylene glycol is used in air sanitization and hard surface disinfection and dipropylene glycol is used in air sanitization.
The chemical, food, and pharmaceutical industries use propylene glycol as antifreeze when leakage might lead to. It is used as a main ingredient in automobile antifreeze and enginecooling liquids and in brake and hydraulic fluids due to its useful properties of low freezing point, involatility and low corrosive activity. It is widely used as a lesstoxic antifreeze, moisturizer in medicines, cosmetics, toothpaste, food, mouth wash and as a solvent for food colors and flavorings. Propylene glycol is commonly used as a substitute for ethylene glycol in low toxicity and environmentally safe antifreeze. Certain bacterial strains convert propylene glycol to pyruvic acid in the presence of thiamine 15. Dow propylene glycol uspep general description propylene glycol uspep pg uspep, referring to the united states and european pharmacopoeias, is a highpurity grade of monopropylene glycol for use in pharmaceutical, food, cosmetic, personal care, flavor and fragrance, plus a variety of other applications. Dailymed systane balance propylene glycol emulsion. Other companies are charging thousands of dollars to set up accounts and. View product specific information, msds, references and buying faq. Show this safety data sheet to the doctor in attendance. Propylene glycol is synthesized from propylene oxide po, cas number 75569, c 3 h 6 o, a colorless liquid at room temperature, and po is present at very low concentrations in the smoke from reference cigarettes diekmann et al.
Propylene glycol dicaprylatedicaprate cas 68583517. Use the product attributes below to configure the comparison table. This material and its container must be disposed of in a safe way. A group of human volunteers were exposed to 719 ppm ethylene glycol by inhalation 2022 hours per day for four weeks. Skin contact wash off immediately with soap and plenty of water removing all contaminated clothes and shoes.
We ask that users who download significant portions of the database cite the. Propylene glycol is a synthetic liquid organic compound with the molecular formula c3h8o2 or ch3chohch2oh. Sccs scientific committee on consumer safety, opinion on methylene glycol, 2627 june 2012 this opinion has been subject to a commenting period of four weeks after its initial publication. Propylene glycol safety data sheet according to federal register vol. Propylene glycol is a highpurity material, which must be handled with special precautions to avoid contamination. Final report on the safety assessment of propylene glycol. Material safety data sheet validation date product and company identification 1.
It is a viscous liquid that is sweet, faint and transparent. Of all polyether polyols incl polypropylene glycol, polyethylene glycol, and propylene oxideethylene oxide copolymers, 65% were used in polyurethane flexible foam. There was no pharmacist intervention when the product was ordered, packaged or picked up at the pharmacy. First aid measures always seek professional medical attention after first aid measures are provided. This is a premixed solution of propylene glycol solution. The inhibitor system is designed to protect brass, copper, solder, steel, cast iron, aluminum, and other metals commonly found in industrial. It has a wide range of other practical applications, e.
It is similar chemically and physiologically to ethylene glycol, albeit less toxic. The most important member of the family is monopropylene glycol, also known as 1,2. Other pertinent literature is also presented, but is described in less detail. Material safety data sheet page 1 of 2 propylene glycol. Clear, colorless and practically odorless liquid, ethylene glycol is completely soluble in water. It is a slightly hazy liquid, free of suspended solids with a slight odor. You have selected the maximum number of product attributes 3 to compare.
Never give anything by mouth to an unconscious person. The subject of the current petition is a request for the approval of propylene glycol to the national list for medical use in organic livestock. Opinion of the scientific committee on consumer safety on. Dow propylene glycol is used as a raw material for the manufacture of other chemicals and as an ingredient in product formulations. Have victim rinse mouth with water, then give one to two glasses of water to drink.
First aid measures general advice consult a physician. In animal studies, propylene glycol has been shown not to interfere with reproduction. Empty containers or liners may retain some product residues. Propylene glycol is used in the plastics industry for the manufacture of polyester fibers and alkyd resins. Propylene glycols are sensitive to oxidizing agents, e. Propylene glycol ip usp fr chemical for cosmetics, foodstuffs. Nsf has processed the application for registration of propylene glycol uspep to the nsf registration. The warning on the propylene glycol bottle for rx compounding is in small print and might be missed. Dow propylene glycol is a viscous, colorless, odorless liquid. Propylene glycol is a compound which is generally recognized as safe gras by the u. Safety data sheet propylene glycol hill brothers chemical. Page 1 the dow chemical company sales specification date printed.
Monopropylene glycol is used in a wide variety of applications, including unsaturated polyester resins, cosmetics and personal care products, functional fluids and antifreezes, liquid detergents, and dog food. Propylene glycol is used as a softening agent, preservative, humectants, and solvent in cosmetics, fragrances, topical medications, soaps and cleansers, hair care products, and deodorants. Firstaid measures description of first aid measures do not induce vomiting. Forensic toxicology laboratory office of chief medical examiner city of new york ethylene glycol and propylene glycol by gas chromatographymass spectrometry principle ethylene glycol hoch2ch2oh is a relatively nonvolatile liquid used as a major component of antifreeze fluids. The premium quality propylene glycol, that we offer to our clients is generally produced in industries by propylene oxide hydration. For detailed safety and health information refer to the material safety data sheet for this product. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Box 4980 the woodlands, tx 77387 telephone numbers transportationemergency chemtrec. Add 36 drops of phenol red ts to 50 ml water, then add 0. Propylene glycol used in animal drugs, feeds, and related products is generally recognized as safe except in cat food when used in accordance with good manufacturing or feeding practice. Wilhelm1 1 department of clinical pharmacology and pharmacy, vrije universiteit medical center, p. Call a physician or poison control center immediately. To the best of our knowledge, this product does not contain chemicals at levels which require reporting under this statute. Download msds pdf search msds currently available for download bioworld offers propylene glycol for your research at low price. Propylene glycol is an aliphatic dihydric alcohol with a wide range of applications in the food industry such as an anticaking agent, antioxidant, humectant, flavoring agent, emulsifier, stabilizer, thickener etc. Chemtrec 8004249300 outside usa 7035273887 1216 6th ave n kent wa 98032 phone. Lc determination of propylene glycol in human plasma after. Propylene glycol is also found in oral treatments as well as many foods.
Lc determination of propylene glycol in human plasma after precolumn derivatization with benzoyl chloride a. It is also designed for use in hydronic systems for freeze and corrosion protection. First aid measures first aid measures eye contact rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Mono ethylene glycol, or simply, ethylene glycol is an organic compound having the molecular formula as ch2ohch2oh. Product codes0575 propylene glycol revision date 08jan2016 4. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Where to use dowfrost propylene glycolbased fluids solutions of dowfrost propylene glycolbased fluids are widely used for secondary cooling and heating applications, for freeze and burst protection of pipes, and for various deicing, defrosting, and dehumidifying applications. Comes premixed with your choice of deoinized water or distilled water. Enter synonyms, trade names or additional information found in section 1. Propylene glycol pg uspep is a pharmacopeiaspecificationsgrade excipient of monopropylene glycol pg or mpg with a specified purity greater than 99. Propylene glycol usp the generation of waste should be avoided or minimized wherever possible. Propylene glycol is an organic compound with many industrial uses. Keep area evacuated and free from ignition sources until any spilled liquid has evaporated ground free from frost.
Answer density is the weight per unit volume of a mass. Propylene glycol is also less acutely toxic than ethylene glycol because the acidosis that it causes does not result in the formation of calcium oxalate crystals. Dispose of surplus and nonrecyclable products via a. Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally. Always drain and flush systems containing propylene glycol with water before welding or other maintenance. To the best of our knowledge, the information contained herein is accurate. Propylene glycol was administered to two groups of female rats at 73 mg or 294 mg propylene glycol 100 gram body weight and various hematological effects were examined. Gunnerson, in critical care nephrology third edition, 2019. Choose between 20 to 50% solutions depending on your thermal or freeze protection required. Propylene glycol is used as a constituent in a large variety of cosmetics, and is approved and used as a vehicle for topical pharmaceutical preparations. Propylene glycol is used as a drench in the treatment of ketosis. Propylene glycol pg has been used as a carrier in fragrance oils. Propylene glycol, dipropylene glycol, and higher glycols are produced commercially from propylene oxide. Air oxidation of propylene glycol using an electrolytic crystalline silver catalyst yields pyruvic aldehyde.
You may download that program for free from this link to adobe exiting. As such, they attract and hold water when exposed to the environment. Density varies with temperature and the graphs below show the densities of dows glycols and glycolwater solutions over a range of temperatures. The 1r4f and 2r4f reference cigarettes were shown to have po concentrations in mainstream smoke of 0. Propylene glycol may exist in air in the vapor form, although it must be heated or briskly shaken to produce a vapor. Safety data sheet the dow chemical company product name.
Propylene glycol is a 3carbon compound derived from propylene which has applications in both industry and medicine. Page 1 material safety data sheet propylene glycol 38%. Propylene glycol pg is a watersoluble alcohol that serves as a solvent in a variety of intravenously administered drugs in the intensive care unit and the general medicine ward. The clear, colorless, slightly syrupy liquid that readily absorbs water is also used to make polyester compounds, and as a base for deicing solutions. The propylene glycols are clear, viscous, colorless liquids that have very little odor, a slightly bittersweet taste, and low vapor pressures. Download our flavors and fragrances catalog to view our entire product line.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Propylene glycol industrial 322560 version 03 revision date. Propylene glycol 1, 2propanediol is an organic compound with multiple uses including. The fda along with other international standards institutions considers it to be generally safe to handle and to ingest and has certified the safety of using propylene glycol in medications, food flavors and for industrial purposes. Propylene glycol is used extensively as a substitute.
Material safety data sheet propylene glycol 38% page 6 additional information. Propylene glycol glycol, 1,2 propandiol 57556 99 100% 2017. Comments received during this time have been considered by the sccs and discussed in the subsequent plenary meeting. Propylene glycol c3h8o2 cid 1030 structure, chemical names, physical and. Ethylene glycol is widely used as an antifreeze and automotive heat transfer fluid. Propylene glycols are hygroscopic liquids and efficient humectants. Nsf international nonfood compounds registration program sandra kupperblatt dow chemical company, the united states midland, mi 48674 february 12, 2004 re. Propylene glycols density values question what are the density values for glycols and glycolwater solutions. Chemistry definition and structure propylene glycol pg is an aliphatic alcohol that conforms to the following formula estrin et al.
Glycols pre inhibited propylene glycol exporter from new. If the pdf does not display below, you may also download it here. Show this safety data sheet to the doctor in advance. Propylene glycol is also present in propylene glycol alginate, which is known as e405. National regulations propylene glycol listed on piccs philippines inventory of chemicals and chemical substances. Pest fleas, mites, red lice, and various bacteria and viruses control for pets cats, dogs, and birds is also a major active use for propylene glycol. Propylene glycol ld50 oral rat 22000 to 3 mgkgld50 dermal rabbit 2 mgkg ingestion. The atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Dipropylene glycol industrial page 3 of 3 for your protection health and safety the safety and health information in this data sheet does not contain sufficient detail for safe handling in all cases. Pdf sources of propylene glycol and glycol ethers in air at. Food and drug administration fda under 21 cfr x184. Intended use of the product use of the substancemixture. Toxicological considerations on the use of propylene. Name, address, and telephone of the responsible party company 1.
Propylene glycol is included in pediculicide drug products. Propylene glycol toxicity in children pubmed central pmc. As an inert ingredient, propylene glycol is formulated into end. This means that you are free to copy, distribute, display and make commercial use of. It is a viscous, colorless liquid, which is nearly. Tuning the surface of au nanoparticles using polyethylene glycolblockpoly propylene glycolblockpolyethylene glycol. Since propylene glycol is used to lower the freezing point of water, its commonly used as a deicer for airport runways and aircraft. Acuros preinhibited propylene glycols is an inhibited propylene glycol based industrial coolant and heat transfer agent. Results a naturallog unit of summed propylene glycol and glycol ethers pges in bedroom air equal to interquartile range, or 3. Propylene glycol tap report agricultural marketing service usda.
329 358 770 1459 539 1595 851 1254 1153 267 1427 1287 1513 511 1025 994 752 151 478 489 1134 469 635 1577 526 1508 873 1603 524 881 1332 261 778 103 817 143 1146 1024 1052 794 254 540